Novel lncRNA-prader willi/angelman region RNA, SNRPN neighbour (PWARSN) aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease.

Yi SongFeng GuoYan-Yan ZhaoXiao-Jun MaLi-Na WuJi-Feng YuHong-Fei JiMing-Wei ShaoFeng-Juan HuangLin ZhaoXun-Jie FanYa-Nan XuQing-Zhu WangGui-Jun Qin

Published in: Cell proliferation (2022)

These findings illustrate distinct dual molecular mechanisms for PWARSN-modulated TXNIP and PTECs pyroptosis in DKD, presenting PWARSN as a promising therapeutic target for DKD.

Keyphrases

nlrp inflammasome
growth hormone
type diabetes
long non coding rna
case report
wound healing