Amyloid precursor protein induces reactive astrogliosis.
Gretsen Velezmoro JaureguiDragana VukićIsaac G OnyangoCarlos AriasJan S NovotnýKateřina TexlováShanshan WangKristina Locker KovačovicovaNatalie PolakovaJana ZelinkovaMaria ČarnaValentina LacovichBrian P HeadDaniel HavasMartin MistrikRobert ZorecAlexei VerkhratskyLiam KeeganMary A O'ConnellRobert RissmanGorazd Bernard StokinPublished in: Acta physiologica (Oxford, England) (2024)
The APP thus represents a candidate molecular inducer and regulator of reactive astrogliosis. This finding has implications for understanding pathophysiology of neurodegenerative and other diseases of the nervous system characterized by reactive astrogliosis and opens potential new therapeutic avenues targeting APP and its pathways to modulate reactive astrogliosis.