Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos.

Qibin QiStephanie M GogartenLeslie S EmeryTin LouieAdrienne StilpJianwen CaiNeil SchneidermanM Larissa Avilés-SantaRobert C KaplanKari E NorthCathy C LaurieRuth J F LoosCarmen R Isasi

Published in: Obesity (Silver Spring, Md.) (2016)

This study confirmed and extended previous findings of IRS1 variation associated with increased adiposity but a favorable metabolic profile in U.S. Hispanics/Latinos, with a relatively stronger genetic effect on BF% in Hispanic/Latino women compared with European women.

Keyphrases

polycystic ovary syndrome
insulin resistance
pregnancy outcomes
african american
cervical cancer screening
breast cancer risk
weight gain
genome wide
type diabetes
metabolic syndrome
skeletal muscle
copy number
dna methylation
weight loss