Cobalt-Catalyzed Oxidative Annulation of Benzothiophene-[b]-1,1-dioxide through Diastereoselective Double C-H Activation.

The use of inexpensive base metal catalysis to perform C-H activation is an active field of research in organic synthesis. Described herein is a sustainable cobalt-catalyzed diastereoselective oxidative annulation/double C-H activation of benzothiophene-[b]-1,1-dioxide with aminoquinolinamides under mild reaction conditions for the synthesis of annulated benzothiophenes.