Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimer's Disease in individuals of African ancestry.
Nicholas R RayBrian W KunkleKara Hamilton-NelsonJiji T KurupFarid RajabliMehmet I CosacakCaghan KizilMelissa Jean-FrancoisMichael CuccaroDolly Reyes-DumeyerLaura CantwellAmanda KuzmaJeffery M VanceSujuan GaoHugh C HendrieOlusegun BaiyewuAdesola OgunniyiRufus O Akinyeminull nullWan-Ping LeeEden R MartinLi-San WangGary W BeechamWilliam S BushLindsay A FarrerJonathan L HainesGoldie S ByrdGerard D SchellenbergRichard P MayeuxMargaret A Pericak-VanceChristiane ReitzPublished in: medRxiv : the preprint server for health sciences (2023)
Increased sample sizes and sample sets from Africa covering as much African genetic diversity as possible will be critical to identify additional disease-associated loci and improve deconvolution of local genetic ancestry effects.