Genome-Wide Reduction in Chromatin Accessibility and Unique Transcription Factor Footprints in Endothelial Cells and Fibroblasts in Scleroderma Skin.
Pei-Suen TsouPamela J PalisocMustafa AliZsuzsanna H McMahanAmr Hakam SawalhaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Our data identify the chromatin blueprint of dcSSc, and suggest that neuronal-related characteristics of SSc ECs and fibroblasts could be a culprit for dysregulated angiogenesis and enhanced fibrosis. Targeting the key pathways and transcription factors identified might present novel therapeutic approaches in SSc.
Keyphrases
- transcription factor
- endothelial cells
- genome wide
- extracellular matrix
- dna binding
- dna methylation
- wound healing
- systemic sclerosis
- vascular endothelial growth factor
- high glucose
- electronic health record
- soft tissue
- genome wide identification
- interstitial lung disease
- big data
- gene expression
- copy number
- machine learning
- oxidative stress
- liver fibrosis