Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.
Richard ShervaCongcong ZhuLeah WetherillHoward J EdenbergEmma JohnsonLouisa DegenhardtArpana AgrawalNicholas G MartinElliot NelsonHenry R KranzlerJoel GelernterLindsay A FarrerPublished in: Exploration of medicine (2021)
Although the two GWS variants are not in genes with obvious links to SUD biology and have modest effect sizes, they are statistically robust and show evidence for association in independent samples. These results may point to novel pathways contributing to disease progression and highlight the utility of related phenotypes to better understand the genetics of SUDs.