Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms.

Brandon M WenzYuan HeNae-Chyun ChenJoseph K PickrellJeremiah H LiMax F DudekTaibo LiRebecca KeenerBenjamin F VoightChristopher D BrownAlexis Battle

Published in: bioRxiv : the preprint server for biology (2024)

Our work provides a proof of principle for caQTL calling from previously ungenotyped samples, and represents one of the largest, most diverse caQTL resources currently available, informing mechanisms of genetic regulation of gene expression and contribution to disease.

Keyphrases

gene expression
genome wide
dna methylation
transcription factor
copy number
dna damage
electronic health record
single cell
artificial intelligence
data analysis