Superior Overall Survival in Patients with Colorectal Cancer, Regular Aspirin Use, and Combined Wild-Type PIK3CA and KRAS-Mutated Tumors.
Leonie GebauerAndrea NistMarco MernbergerThorsten StieweRoland MollKathleen StablaUwe KlingeElisabeth K M MackCornelia BrendelAndreas NeubauerPublished in: Cancers (2021)
The impact of aspirin use after the diagnosis of colorectal cancer is unknown. Among others, PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) mutational status was proposed as a molecular biomarker for the response to adjuvant aspirin therapy. However, prognostic data on aspirin use after a colorectal cancer diagnosis in relation to KRAS mutational status is limited. In a single-center retrospective study, we obtained KRAS and PIK3CA mutational status in a cohort of 153 patients with a first diagnosis of colorectal cancer receiving tumor surgery with curative intent. PIK3CA mutational status was determined by pyrosequencing, and KRAS mutational status was determined by next-generation sequencing. Clinicopathological data and survival data were assessed using patient records and reporting registers. We observed a significant 10-year overall survival benefit in patients with aspirin use and combined wild-type PIK3CA and mutated-KRAS tumors (HR = 0.38; 95% CI = 0.17-0.87; p = 0.02), but not in patients without aspirin use. Our data indicate a benefit of aspirin usage particularly for patients with combined wild-type PIK3CA and mutated-KRAS tumor characteristics.
Keyphrases
- wild type
- low dose
- protein kinase
- cardiovascular events
- antiplatelet therapy
- electronic health record
- big data
- anti inflammatory drugs
- acute coronary syndrome
- end stage renal disease
- minimally invasive
- coronary artery disease
- ejection fraction
- percutaneous coronary intervention
- prognostic factors
- cardiovascular disease
- emergency department
- type diabetes
- stem cells
- chronic kidney disease
- dna methylation
- rectal cancer
- patient reported outcomes
- data analysis
- cell therapy
- coronary artery bypass
- adverse drug
- copy number
- atrial fibrillation
- bone marrow
- peritoneal dialysis
- patient reported
- tyrosine kinase
- cell free
- single molecule