Harmonization of LC-MS/MS Measurements of Plasma Free Normetanephrine, Metanephrine, and 3-Methoxytyramine.
Mirko PeitzschTalia NovosDenise KadenMax KurlbaumAntonius E van HerwaardenDaniel MüllerJo AdawayEric GrouzmannBrett McWhinneyKirsten HoadGerald WoollardIdo KemaChristopher BootMartin FassnachtFred SweepTze P LohAndrea R HorvathGraeme EisenhoferPublished in: Clinical chemistry (2022)
Analytical methods for metanephrines are well harmonized between laboratories. However, the 16% disagreement in test interpretation for normetanephrine suggests use of suboptimal method-dependent reference intervals for clinical decision-making for this metabolite. Improved analytical methods and reference interval harmonization are particularly required for 3-methoxytyramine.
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