Native low density lipoprotein increases the production of both nitric oxide and reactive oxygen species in the human umbilical vein endothelial cells.
Hyun Joong YoonKee Oh ChaySung Yeul YangPublished in: Genes & genomics (2019)
These findings suggest that oxidative stress originated from induction of iNOS and eNOS could be a causative factor for nLDL-induced senescence of HUVECs.
Keyphrases
- endothelial cells
- high glucose
- low density lipoprotein
- nitric oxide
- nitric oxide synthase
- reactive oxygen species
- oxidative stress
- diabetic rats
- dna damage
- vascular endothelial growth factor
- ischemia reperfusion injury
- cell proliferation
- stress induced
- heat shock
- endoplasmic reticulum stress
- heat stress
- heat shock protein