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ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair.

Nho Cong LuongHidemasa KawamuraHiroko IkedaReiko T RoppongiAtsushi ShibataJiaxuan HuJinmeng G JiangDavid S YuKathryn D Held
Published in: International journal of radiation biology (2024)
Our results indicate that HTB94 cells were likely more efficient in DNA repair than AG01522 cells, specifically via ATR signaling, which inhibited the bystander signal-induced MN formation. This study highlights the significance of DNA repair efficiency in bystander cell responses.
Keyphrases
  • dna repair
  • dna damage
  • dna damage response
  • induced apoptosis
  • cell cycle arrest
  • endothelial cells
  • signaling pathway
  • cell death
  • single cell
  • cell proliferation
  • bone marrow
  • mesenchymal stem cells
  • drug induced