Clinical Utility of LC-MS/MS for Blood Myo-Inositol in Patients with Acute Kidney Injury and Chronic Kidney Disease.

Catherine L OmosuleConnor J BlairElizabeth HerriesMark A ZaydmanChristopher W FarnsworthJack LadensonDennis J DietzenJoseph P Gaut

Published in: Clinical chemistry (2024)

This study unveils MI as a potential renal biomarker, notably elevated in plasma during AKI and CKD. Plasma MI rises 33 h prior to serum creatinine, enabling early AKI detection. Further validation and exploration of MI quantitation in kidney disease diagnosis is warranted.

Keyphrases

acute kidney injury
chronic kidney disease
cardiac surgery
end stage renal disease
mass spectrometry
metabolic syndrome
uric acid
climate change