Sensitivity of docetaxel-resistant MCF-7 breast cancer cells to microtubule-destabilizing agents including vinca alkaloids and colchicine-site binding agents.

Richard C WangXinmei ChenAmadeo M ParissentiAnil A JoyJack TuszynskiDavid N BrindleyZhixiang Wang

Published in: PloS one (2017)

Docetaxel-resistant MCF-7TXT cells have demonstrated cross-resistance to vinca alkaloids, but appear to be more sensitive to CSBAs (colchicine, 2MeOE2, ABT-751 and CA-4P) compared to non-resistant MCF-7CC cells. Taken together these results suggest that CSBAs should be evaluated further in the treatment of taxane resistant breast cancer.

Keyphrases

breast cancer cells
induced apoptosis
cell cycle arrest
locally advanced
cell proliferation
transcription factor
dna binding
rectal cancer