Evaluation of amikacin dosing schedule in critically ill elderly patients with different stages of renal dysfunction.
Saeideh GhaffariAli Mohammad HadiFarhad NajmeddinBita ShahramiMohammad-Reza RouiniAtabak NajafiMojtaba MojtahedzadehPublished in: European journal of hospital pharmacy : science and practice (2021)
The initial dosing of amikacin in critically ill elderly patients should not be reduced, even in the context of renal impairment. Regarding the dose adjustment in renal impairment, dosing intervals estimation, no decision can be made based on the creatinine clearance and the first dose individualisation method in terms of the two-sample measurements may be considered as an appropriate strategy.