Chronic 3,4-Methylenedioxymethamphetamine (MDMA) use is related to glutamate and GABA concentrations in the striatum, but not in the anterior cingulate cortex.
Josua ZimmermannNiklaus ZölchRebecca CorayFrancesco BavatoNicole FriedliMarkus R BaumgartnerAndrea E SteuerAntje OpitzAnnett WernerGeorg OeltzschnerErich SeifritzAnn Kathrin StockChristian BesteDavid M ColeFrancesco BavatoPublished in: The international journal of neuropsychopharmacology (2023)
Our findings suggest that MDMA use affects not only serotonin, but also striatal GLX and GABA concentrations. These insights may offer new mechanistic explanations for cognitive deficits (e.g., impaired impulse control) observed in MDMA users.