Association between Tumor Acidity and Hypervascularity in Human Gliomas Using pH-Weighted Amine Chemical Exchange Saturation Transfer Echo-Planar Imaging and Dynamic Susceptibility Contrast Perfusion MRI at 3T.

Y-L Wang Jingwen Yao Ararat Chakhoyan Catalina Raymond Noriko Salamon Linda M Liau Phioanh Leia Nghiemphu Albert Lai Whitney B Pope N Nguyen M Ji Timothy F Cloughesy Benjamin M Ellingson

Published in: AJNR. American journal of neuroradiology (2019)

A positive linear correlation between CBV and acidity in areas of T2-hyperintense, nonenhancing tumor, but not enhancing tumor, was observed across patients. Local heterogeneity was observed within individual tumors.

Keyphrases

contrast enhanced
magnetic resonance
magnetic resonance imaging
end stage renal disease
diffusion weighted
endothelial cells
newly diagnosed
ejection fraction
high resolution
diffusion weighted imaging
prognostic factors
high grade
mass spectrometry