ERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study.

Robert J FontanaYi Ju Li Raj K Vuppalanchi David E KleinerJiezhun GuHersh Shroff Lisa B Van WagnerPaul B Watkinsnull null

Published in: The American journal of gastroenterology (2024)

Acute liver injury may arise within 8 weeks of COVID-19 mRNA vaccination that is generally mild and self-limited in most patients. The absence of an association with the AIH HLA alleles combined with the significant ERAP-2 and ERAP-1 Hap6 haplotype associations implicates a unique but very rare host immune response to vaccine-derived antigens in the pathogenesis of COVID-19 vaccine hepatotoxicity.

Keyphrases

liver injury
drug induced
coronavirus disease
sars cov
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
dendritic cells
immune response
copy number
liver failure
dna methylation
patient reported outcomes
preterm birth