Can adult polygenic scores improve prediction of body mass index in childhood?
Katherine LangeJessica A KerrToby MansellJustin Martin O'SullivanDavid P BurgnerSusan A CliffordTim OldsTerence DwyerMelissa WakeRichard SafferyPublished in: International journal of obesity (2005) (2022)
Adult-derived PGSs for BMI, particularly those derived by modelling between-variant interactions, may be useful for predicting BMI during adolescence with similar accuracy to that obtained in adulthood. The level of precision presented here to predict BMI during childhood may be relevant to public health, but is likely to be less useful for individual clinical purposes.