An anti-alcoholism drug, disulfiram and copper complex improves radio-resistance of tumor-initiating cells in esophageal squamous cell carcinoma.
Li QianKentaro MurakamiTakeshi ToyozumiYasunori MatsumotoRyota OtsukaNobufumi SekinoSatoshi EndoKazuya KinoshitaTakuma SasakiHisahiro MatsubaraPublished in: Esophagus : official journal of the Japan Esophageal Society (2022)
ALDH1 inhibition by the DSF/Cu complex enhances the radiosensitivity of TICs in ESCC. The drug repositioning approach using disulfiram is a potential treatment option to overcome radioresistance in patients with locally advanced ESCC.
Keyphrases
- replacement therapy
- locally advanced
- induced apoptosis
- squamous cell carcinoma
- cell cycle arrest
- rectal cancer
- neoadjuvant chemotherapy
- adverse drug
- radiation therapy
- endoplasmic reticulum stress
- drug induced
- emergency department
- clinical trial
- human health
- dna damage
- combination therapy
- cancer stem cells
- aqueous solution
- dna repair
- metal organic framework