SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia-reperfusion injury.
Meng MaoQian XiaGao-Feng ZhanQin-Jun ChuXing LiHong-Kai LianPublished in: Cell & bioscience (2022)
We demonstrated a previously unidentified mechanism by which SENP6-mediated ANXA1 de-SUMOylation regulates microglial polarization and our results strongly indicated that in microglia, inhibition of SENP6 may be a crucial beneficial therapeutic strategy for ischaemic stroke.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- cerebral ischemia
- neuropathic pain
- subarachnoid hemorrhage
- acute myocardial infarction
- blood brain barrier
- brain injury
- traumatic brain injury
- spinal cord injury
- spinal cord
- acute ischemic stroke
- cognitive impairment
- heart failure
- percutaneous coronary intervention
- cerebral blood flow