Discovery of Fungus-Derived Nornidulin as a Novel TMEM16A Inhibitor: A Potential Therapy to Inhibit Mucus Secretion in Asthma.

Pawin PongkorpsakolChantapol YimnualWilasinee SatianrapapongNichakorn WorakajitSuchada KaewinPraphatsorn SaetangVatcharin RukachaisirikulChatchai Muanprasat

Published in: Journal of experimental pharmacology (2023)

Our study revealed that nornidulin is a novel TMEM16A inhibitor that suppresses mucus secretion without compromising immunologic activity. Further development of nornidulin may provide a new remedy for asthma or other diseases associated with allergic mucus hypersecretion without causing opportunistic infections.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
small molecule
signaling pathway
high throughput
single cell
risk assessment
cystic fibrosis
air pollution
human health
mesenchymal stem cells