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Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease.

Rebekah M DedrickKrista G FreemanJan A NguyenAsli Bahadirli-TalbottMitchell E CardinMadison CristinzianoBailey E SmithSoowan JeongElisa H IgnatiusCheng Ting LinKeira A CohenGraham F Hatfull
Published in: Open forum infectious diseases (2022)
An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.
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