Genetic diversity of Gerbich alleles in Brazilians reveals an unexpected prevalence of the GE:-2,-3,4 phenotype.

Carine Prisco ArnoniNayara Morais SilvaFlavia Sant'Anna SilvaRafael Martins ParreiraTatiane Aparecida de Paula Vendrame Marcos Paulo MiolaJanaína MunizAfonso CortezMarilia ValvasoriEvanilde Pereira de AraujoLeandro Felipe Figueiredo DalmazzoAlyne FreitasFlavia LatiniLilian Castilho

Published in: Vox sanguinis (2023)

This study showed for the first time the genetic diversity of GYPC alleles for carriers of Gerbich-negative phenotypes in a Brazilian population and showed an unexpected prevalence of the GE:-2,-3,4 phenotype. It also demonstrated the importance of using molecular tools to correctly classify Gerbich phenotypes for selection of variants in antigen-matched transfusions.

Keyphrases

genetic diversity
risk factors
copy number
gene expression
single molecule