Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis.

Ruey-Hwa Chen

Published in: Molecular cell (2024)

In a recent publication in Nature, Xu et al. 1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.

Keyphrases

single molecule
copy number
gene expression
mouse model
genome wide