Login / Signup

The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish.

Catherine M ScahillZsofia DigbyIan M SealyRichard J WhiteNeha WaliJohn E CollinsDerek L StempleElisabeth M Busch-Nentwich
Published in: Wellcome open research (2017)
These data indicate that the phenotypes observed in offspring from older parents cannot be explained by telomere length. Instead we propose that Tert functions outside of telomere length maintenance in an age-dependent manner to influence the adult phenotypes of the next generation.
Keyphrases
  • high fat diet
  • early onset
  • physical activity
  • big data
  • type diabetes
  • middle aged
  • adipose tissue
  • community dwelling
  • machine learning
  • wild type