The Effects of Anti-Vascular Endothelial Growth Factor Drugs on Retinal Pigment Epithelial Cell Culture.

Mustafa ŞahinerDilek BaharAyşe ÖnerZeynep Burçin Gönen Metin Unlu Duygu Gulmez Sevim Cagatay KaracaGalip Ertuğrul Mirza

Published in: Turkish journal of ophthalmology (2018)

Anti-VEGF drugs did not affect senescence or proliferation of retinal pigment epithelium cells. Aflibercept was found to decrease apoptosis and increase cell viability, while ranibizumab and bevacizumab increased apoptosis and reduced cell viability in retinal pigment epithelium culture.

Keyphrases

vascular endothelial growth factor
cell cycle arrest
cell death
endothelial cells
endoplasmic reticulum stress
induced apoptosis
pi k akt
oxidative stress
signaling pathway
age related macular degeneration
dna damage
diabetic retinopathy
cell proliferation
metastatic colorectal cancer