Insulin Resistance in Women Correlates with Chromatin Histone Lysine Acetylation, Inflammatory Signaling, and Accelerated Aging.

Christina M VidalJackelyn A Alva-OrnelasNancy Zhuo ChenParijat Senapati Jerneja TomsicVanessa Myriam RoblesCristal RestoNancy SanchezAngelica SanchezTerry HyslopNour Emwas Dana AljaberNick BachelderErnest MartinezDavid AnnVeronica JonesRobert A Winn Lucio Miele Augusto C OchoaEric C DietzeRama NatarajanDustin SchonesVictoria E Seewaldt

Published in: Cancers (2024)

This study shows that insulin-resistant women have increased chromatin acetylation/opening, inflammation, and, perhaps, accelerated aging. Given the role that inflammation plays in cancer initiation and progression, these studies provide a potential mechanistic link between insulin resistance and cancer.

Keyphrases

polycystic ovary syndrome
oxidative stress
papillary thyroid
insulin resistance
type diabetes
dna damage
gene expression
squamous cell
pregnancy outcomes
metabolic syndrome
adipose tissue
pregnant women
high fat diet
histone deacetylase
risk assessment
breast cancer risk