Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals.
Luigi LorenziniLyduine E CollijNiccoló TesiNatàlia Vilor-TejedorSilvia IngalaKaj BlennowChristopher FoleyGiovanni B FrisoniSven HallerHenne HolstegeSven van der van der LeePablo Martinez-LageRiccardo E MarioniDaniel L McCartneyJohn O' BrienTiago Gil OliveiraPierre PayouxMarcel ReindersCraig RitchiePhilip ScheltensAdam J SchwarzCarole H SudreAdam D WaldmanRobin WolzGael ChatelatMichael EwersAlle Meije WinkHenk J M M MutsaertsJuan Domingo GispertPieter Jelle VisserBetty M TijmsAndre AltmannFrederik BarkhofPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Polygenic risk for Alzheimer's disease encompasses six biological pathways that can be quantified with pathway-specific genetic risk scores, and differentially relate to cerebrospinal fluid and imaging biomarkers. Inflammatory pathways are mostly related to cerebrovascular burden. White matter health is associated with pathways of clearance and membrane integrity, whereas functional connectivity measures are related to signal transduction and synaptic communication pathways.