Menthol blunts the interoceptive discriminative stimulus effects of nicotine in female but not male rats.
Y Wendy HuynhAnthony RaimondiAndrew FinknerJordan D KuckCarly SelleckRick A BevinsPublished in: Psychopharmacology (2020)
Female rats that were trained with 0.1 mg/kg nicotine were more sensitive to menthol's modulatory effects on nicotine's stimulus effects. This highlights the importance of taking sex and training dose into account when evaluating the interoceptive stimulus effects of nicotine and menthol.