RRx-001 protects normal tissues but not tumors via Nrf2 induction and Bcl-2 inhibition.

Bryan OronskyCurtis ScribnerRahul AggarwalPedro Cabrales

Published in: Journal of cancer research and clinical oncology (2019)

Through Nrf2 induction in normal cells and inhibition of Bcl-2 in tumor cells, RRx-001 selectively protects normal cells against lethality in normal cells, but induces apoptosis in tumor cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
signaling pathway
cell proliferation
pi k akt