Distinct Fos-Expressing Neuronal Ensembles in the Ventromedial Prefrontal Cortex Mediate Food Reward and Extinction Memories.
Brandon L WarrenMichael P MendozaFabio C CruzRodrigo M LeaoDaniele CaprioliF Javier RubioLeslie R WhitakerKylie B McPhersonJennifer M BossertYavin ShahamBruce T HopePublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
A current popular hypothesis is that neuronal ensembles in different prefrontal cortex areas control reward-associated versus extinction-associated memories: the dorsal medial prefrontal cortex (mPFC) promotes reward seeking, whereas the ventral mPFC inhibits reward seeking. In this paper, we use the Daun02 chemogenetic inactivation procedure to demonstrate that Fos-expressing neuronal ensembles mediating both food reward and extinction memories intermingle within the same ventral mPFC area.