IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo.

Shreya GhimireBiyun XueKun LiRyan M GannonChristine L Wohlford-LenaneAndrew L ThurmanHuiyu GongGrace C NeckerJian ZhengDavid K Meyerholz Stanley Perlman Paul B McCray Alejandro A Pezzulo

Published in: bioRxiv : the preprint server for biology (2024)

G2D plays a crucial role in the IL-13-driven exacerbation of COVID-19 in mice, suggesting that targeting the IL-13-PLA2G2D axis could help protect against SARS-CoV-2 infection. These insights are important for clinical research, especially for studies focusing on drugs that modify IL-13 signaling or modulate eicosanoids in the treatment of asthma and respiratory virus-induced lung diseases.

Keyphrases

diabetic rats
chronic obstructive pulmonary disease
coronavirus disease
sars cov
respiratory syndrome coronavirus
lung function
metabolic syndrome
cystic fibrosis
insulin resistance
intensive care unit
mechanical ventilation
allergic rhinitis
respiratory failure
high glucose