Voltammetric Determination of Isoniazid in the Presence of Acetaminophen Utilizing MoS 2 -Nanosheet-Modified Screen-Printed Electrode.
Somayeh TajikZahra DourandishFariba Garkani NejadAbbas Aghaei AfsharHadi BeitollahiPublished in: Micromachines (2022)
We used MoS 2 nanosheets (MoS 2 NSs) for surface modification of screen-printed electrode (MoS 2 NSs-SPE) aimed at detecting isoniazid (INZ) in the presence of acetaminophen (AC). According to analysis, an impressive catalytic performance was found for INZ and AC electro-oxidation, resulting in an appreciable peak resolution (~320 mV) for both analytes. Chronoamperometry, differential pulse voltammetry (DPV), linear sweep voltammogram (LSV), and cyclic voltammetry (CV) were employed to characterize the electrochemical behaviors of the modified electrode for the INZ detection. Under the optimal circumstances, there was a linear relationship between the peak current of oxidation and the various levels of INZ (0.035-390.0 µM), with a narrow limit of detection (10.0 nM). The applicability of the as-developed sensor was confirmed by determining the INZ and AC in tablets and urine specimens, with acceptable recoveries.
Keyphrases
- reduced graphene oxide
- quantum dots
- visible light
- gold nanoparticles
- room temperature
- transition metal
- label free
- mycobacterium tuberculosis
- molecularly imprinted
- highly efficient
- carbon nanotubes
- high throughput
- solid phase extraction
- liver injury
- hydrogen peroxide
- sensitive detection
- blood pressure
- ms ms
- low cost
- drug induced
- electron transfer
- high resolution
- ultrasound guided