Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients.
Yuki ImaokaMasahiro OhiraRyosuke NakanoSeiichi ShimizuShintaro KurodaHiroyuki TaharaKentaro IdeTsuyoshi KobayashiHideki OhdanPublished in: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2019)
Abdominal aortic calcification (AAC) is known as a risk factor of coronary artery disease, stroke, hyperphosphatemia, chronic inflammation, diabetes, and decreased estimated glomerular filtration rate. However, the clinical implications of incidental AAC findings in liver transplantation (LT) have not been evaluated in terms of posttransplantation survival and complications. Therefore, we analyzed the relationships between the AAC level and the outcomes following LT. A total of 156 consecutive patients who underwent LT between January 2007 and December 2014 were divided into 2 groups according to their AAC level (<100 mm3 or ≥100 mm3 ), as calculated using the Agatston method. Even after propensity matching, the survival time was significantly longer in the low-AAC group compared with that in the high-AAC group (median survival time, 4.5 versus 3.0 years; P < 0.01). A multivariate analysis identified high AAC level (hazard ratio, 2.2) and old donor age (hazard ratio, 2.2) as prognostic factors for overall survival. In conclusion, high AAC is an independent unfavorable prognostic factor in LT.
Keyphrases
- prognostic factors
- abdominal aortic
- coronary artery disease
- chronic kidney disease
- risk factors
- free survival
- end stage renal disease
- type diabetes
- cardiovascular disease
- oxidative stress
- newly diagnosed
- ejection fraction
- atrial fibrillation
- heart failure
- metabolic syndrome
- insulin resistance
- cardiovascular events
- left ventricular
- coronary artery bypass grafting
- data analysis
- aortic stenosis
- cerebral ischemia