Continuous-Flow Synthesis of Δ 9 -Tetrahydrocannabinol and Δ 8 -Tetrahydrocannabinol from Cannabidiol.
Benedetta BassettiChristopher A HoneC Oliver KappePublished in: The Journal of organic chemistry (2023)
A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This step typically affords a mixture of products, which requires extensive purification to obtain any pure products. We report the development of two continuous-flow protocols for the preparation of (-)- trans -Δ 9 -tetrahydrocannabinol and (-)- trans -Δ 8 -tetrahydrocannabinol.
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