Marginal zone B cells produce 'natural' atheroprotective IgM antibodies in a T cell-dependent manner.

James HarrisonStephen A NewlandWei JiangDespoina GiakomidiXiaohui ZhaoMarc ClementLeanne MastersAndrej CorovicXian ZhangFabrizio DragoMarcella MaMaria Ozsvar KozmaFroher YasinYuta SaadyHema KothariTian X ZhaoGuo Ping ShiColeen A McNamaraChristoph J BinderAndrew P SageJason M Tarkin Ziad Mallat Meritxell Nus

Published in: Cardiovascular research (2024)

Our findings reveal a previously unsuspected role of MZB cells in regulating atheroprotective 'natural' IgM antibody production in a Tfh-dependent manner, which could have important pathophysiological and therapeutic implications.

Keyphrases

induced apoptosis
cell cycle arrest
genome wide
endoplasmic reticulum stress
single cell
oxidative stress
gene expression