Modulatory activity of testosterone on growth pattern and IGF-1 levels in vanishing testis syndrome: a case report during 15 years of follow-up.

Marta FrancoKeyvan Khorrami ChokamiManuela AlbertelliClaudia TetiFrancesco CocchiaraFederico GattoCarlo TrombettaDiego Ferone Mara Boschetti

Published in: BMC endocrine disorders (2023)

Testosterone levels act an important role during pubertal spurt in modulating the GH/IGF-1 axis, besides its well-known impact in sexual development. Very little amount of exogenous testosterone can stimulate IGF-1 secretion and provide to growth velocity the drive that characterizes the initial phases of the growth spurt.

Keyphrases

replacement therapy
growth hormone
pi k akt
binding protein
signaling pathway
mental health
cell proliferation
blood flow