Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability.
Yuanquan YangRohit K JainSean T GlennBo XuPrashant K SinghLei WeiQiang HuMark LongNicholas HutsonJianming WangSebastiano BattagliaSaby GeorgePublished in: Journal for immunotherapy of cancer (2020)
The novel MSH4 L359I mutation is associated with MSI and high mutational burden leading to remarkable response to PD-L1 blockade. More studies are warranted to establish the causality relationship between MSH4 and MSI.