Editan (Lasianthera africana) leaf-inclusive diets modulate some neuronal enzyme activities and antioxidant status of cyclophosphamide-treated Wistar rats.

The effect of Editan (Lasianthera africana) leaf inclusive diet (ELD) on neuronal cholinesterases (ChE), ecto-5'-nucleotidase, and endogenous antioxidant indices [superoxide dismutase (SOD), catalase (CAT), glutathione (GSH)] in cyclophosphamide (CYP)-administered albino rats were investigated. Thirty male albino Wistar rats were dissevered appropriately (n = 6). Group I-normal control rats (NC), II-untreated CYP-administered rats, III-CYP-administered rats pre-treated with donepezil (DON), group IV-CYP-administered rats fed ELD, and V-normal rats fed with ELD for 21 days. Results obtained revealed that CYP-administered rats significantly (p < .05) had elevated activities of ChE, ecto-5'-nucleotidase and thiobarbituric acid reactive species (TBARS), and concomitantly decreased in the antioxidant indices. However, pre-treatment with either DON or ELD reversed these effects, thereby eliciting a therapeutic effect which could be linked to the rich polyphenol and alkaloid constituents in the studied leaf, and could be responsible for the potential ethnopharmacological actions of the ELD in the management neurodegeneration. PRACTICAL APPLICATIONS: Currently, the use of plant-food to control diseased conditions due to their phytochemicals has been explored, most especially, the indigenous edible vegetables from the Southwestern part of Nigeria. "Editan" leafy vegetable scientifically known as Lasianthera africana is commonly used in soups preparation and in folklore for the management of some human ailments. Editan leaf is a rich source of alkaloid and phenolic compounds, which could be used to treat and or manage neurological diseases. This study, therefore, unravels the fact that the studied leafy vegetable possesses therapeutic potentials toward the management of neurological disorders.