Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice.

Bingning DongYing ZhouWei WangJessica ScottKangHo KimZhen SunQi GuoYang LuNaomi M GonzalesHuaizhu WuSean M HartigRobert Brian YorkFeng YangDavid D Moore

Published in: Hepatology (Baltimore, Md.) (2020)

Activation of liver macrophage VDRs by vitamin D ligands ameliorates liver inflammation, steatosis and insulin resistance. Our results suggest therapeutic paradigms for treatment of NAFLD and type 2 diabetes mellitus.

Keyphrases

insulin resistance
high fat diet induced
high fat diet
adipose tissue
oxidative stress
type diabetes
skeletal muscle
mouse model
polycystic ovary syndrome
weight loss
wild type