Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in Pseudomonas aeruginosa .
Caleb M SchwartzkopfVéronique L TaylorMarie-Christine GroleauDominick R FaithAmelia K SchmidtTyrza L LammaDiane M BrooksEric DézielKaren L MaxwellPatrick R SecorPublished in: bioRxiv : the preprint server for biology (2023)
. The Pf phage protein PfsE inhibits PQS-mediated quorum sensing by binding to the host enzyme PqsA, while also protecting against type IV pili-dependent phage infection. This dual inhibition strategy promotes Pf replication and safeguards the host from competing phages.