Liver-innervating vagal sensory neurons play an indispensable role in the development of hepatic steatosis and anxiety-like behavior in mice fed a high-fat diet.
Jiyeon HwangJunichi OkadaJeffrey E PessinStreamson C ChuaGary J SchwartzYoung-Hwan JoPublished in: bioRxiv : the preprint server for biology (2024)
The liver-brain axis contributes to the regulation of energy balance, glucose tolerance, hepatic steatosis, and anxiety-like behavior depending on the nutrient status in healthy and obesogenic conditions.