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Liver-innervating vagal sensory neurons play an indispensable role in the development of hepatic steatosis and anxiety-like behavior in mice fed a high-fat diet.

Jiyeon HwangJunichi OkadaJeffrey E PessinStreamson C ChuaGary J SchwartzYoung-Hwan Jo
Published in: bioRxiv : the preprint server for biology (2024)
The liver-brain axis contributes to the regulation of energy balance, glucose tolerance, hepatic steatosis, and anxiety-like behavior depending on the nutrient status in healthy and obesogenic conditions.
Keyphrases
  • high fat diet
  • insulin resistance
  • adipose tissue
  • sleep quality
  • high fat diet induced
  • spinal cord
  • white matter
  • brain injury
  • wild type