Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet.
Jie SunYan LiuJinjin ZhangHuilin ShiRujiao JiangMeihua GuoYilin LiuBo LiuNing WangRui MaDanna ZhangFang ZhangShujing WangYingjie WuPublished in: Molecular nutrition & food research (2024)
These findings suggest that puerarin mitigates insulin resistance by inhibiting ER stress and suppressing inflammation through the JNK and IKKβ/NF-κB pathways. This highlights the promising clinical application of puerarin in the treatment of insulin resistance.
Keyphrases
- signaling pathway
- insulin resistance
- high fat diet
- induced apoptosis
- adipose tissue
- endoplasmic reticulum stress
- high fat diet induced
- pi k akt
- oxidative stress
- metabolic syndrome
- skeletal muscle
- polycystic ovary syndrome
- type diabetes
- radiation induced
- glycemic control
- lps induced
- combination therapy
- radiation therapy
- replacement therapy
- inflammatory response