Hypoxic stress accelerates the propagation of pathological alpha-synuclein and degeneration of dopaminergic neurons.

Mengyuan GuoWeijin LiuHanjiang LuoQianqian ShaoYuning LiYakun GuYuying GuanWei MaMin ChenHui YangXun-Ming Ji Jia Liu

Published in: CNS neuroscience & therapeutics (2022)

Hypoxia was shown to accelerate the pathological progression and damage phenotype in PD model mice. The results provided a promising research target for determining common interventions for PD in the future.

Keyphrases

physical activity
spinal cord
oxidative stress
current status
high fat diet induced
type diabetes
metabolic syndrome
adipose tissue
spinal cord injury
wild type