Early lymphocyte collection for anti-CD19 CART production improves T-cell fitness in patients with relapsed/refractory diffuse large B-cell lymphoma.
T Dubnikov SharonM AssayagBatia AvniS Kfir-ErenfeldE LebelMoshe E E GattN GoldschmidtPolina StepenskyNathalie AsherieSigal GrisariuPublished in: British journal of haematology (2023)
While improved T-cell phenotype and function in the lymphopheresis product did not translate into significantly improved clinical outcomes, a trend towards better overall survival (OS) and progression-free survival (PFS) was observed. Early lymphopheresis maximizes the potential of salvage therapies, without compromising CAR T-cell quality.