Both periodontitis and Coronavirus disease 2019 (COVID-19) pose grave threats to public health and social order, endanger human life, and place a significant financial strain on the global healthcare system. Since the COVID-19 pandemic, mounting research has revealed a link between COVID-19 and periodontitis. It is critical to comprehend the immunological mechanisms of the two illnesses as well as their immunological interaction. Much evidence showed that there are many similar inflammatory pathways between periodontitis and COVID-19, such as NF-κB pathway, NLRP3/IL-1β pathway, and IL-6 signaling pathway. Common risk factors such as gender, lifestyle, and comorbidities contribute to the severity of both diseases. Revealing the internal relationship between the two diseases is conducive to the treatment of the two diseases in an emergency period. It is also critical to maintain good oral hygiene and a positive attitude during treatment. This review covers four main areas: immunological mechanisms, common risk factors, evidence of the association between the two diseases, and possible interventions and potential targets. These will provide potential ideas for drug development and clinical treatment of the two diseases.
Keyphrases
- coronavirus disease
- sars cov
- public health
- risk factors
- signaling pathway
- respiratory syndrome coronavirus
- healthcare
- emergency department
- endothelial cells
- oxidative stress
- mental health
- pi k akt
- physical activity
- metabolic syndrome
- cardiovascular disease
- cell proliferation
- immune response
- single cell
- weight loss
- combination therapy
- risk assessment
- induced apoptosis
- replacement therapy
- inflammatory response
- oral health
- childhood cancer