Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration.

Irina BalikovaLaurence PostelmansBrigitte PasteelsPascale CoqueletJanet CatherineAzra EfendicYoshikatsu HosodaMasahiro MiyakeKenji Yamashironull nullBernard ThienpontDiether Lambrechts

Published in: BMJ open ophthalmology (2019)

Identifying genetic variants that define treatment response can help to develop individualised therapeutic approaches for wet ARMD patients and may point towards new targets in non-responders.

Keyphrases

age related macular degeneration
end stage renal disease
vascular endothelial growth factor
ejection fraction
endothelial cells
newly diagnosed
chronic kidney disease
peritoneal dialysis
stem cells
gene expression
genome wide
patient reported outcomes
cell therapy
replacement therapy