Validation of a yellow fever vaccine model using data from primary vaccination in children and adults, re-vaccination and dose-response in adults and studies with immunocompromised individuals.

Carla Rezende Barbosa BoninGuilherme Côrtes FernandesReinaldo de Menezes MartinsLuiz Antonio Bastos CamachoAndréa Teixeira-CarvalhoLicia Maria Henrique da MotaSheila Maria Barbosa de LimaAna Carolina Campi-AzevedoOlindo Assis Martins-FilhoRodrigo Weber Dos SantosMarcelo Lobosconull null

Published in: BMC bioinformatics (2020)

Our simulations show that the minimum dose to confer immunity against YF is half of the reference dose. The results also suggest that immunological immaturity in children limits the induction and persistence of long-lived plasma cells are related to the antibody decay observed experimentally. Finally, the decay observed in the antibody level after ten years suggests that a booster dose is necessary to keep immunity against YF.

Keyphrases

young adults
induced apoptosis
electronic health record
molecular dynamics
big data
cell proliferation
intensive care unit
oxidative stress
machine learning
respiratory failure
clinical evaluation