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Cascade strategy for triggered radical release by magnetic nanoparticles grafted with thermosensitive alkoxyamine.

Basile BouvetSaad SeneGautier FélixJeffrey HavotGerard AudranSylvain R A MarqueJoulia LarionovaYannick Guari
Published in: Nanoscale (2022)
The design of smart nanoplatforms presenting well-definite structures able to achieve controlled cascade action remotely triggered by external stimuli presents a great challenge. We report here a new nanosystem consisting of magnetic iron oxide nanoparticles covalently grafted with a thermosensitive radical initiator alkoxyamine, able to provide controlled and localized release of free radicals triggered by an alternating current (ac) magnetic field. These nanoparticles exhibit a high intrinsic loss power of 4.73 nHm 2 kg -1 providing rapid heating of their surface under the action of an ac field, inducing the homolysis of alkoxyamine C-ON bond and then the oxygen-independent formation of radicals. This latter was demonstrated by electronic paramagnetic resonance spectroscopy, and the kinetics of homolysis has been investigated allowing a comparison of the temperature of alkoxyamine's homolysis with the one measured during the magnetothermia process.
Keyphrases
  • magnetic nanoparticles
  • iron oxide nanoparticles
  • high resolution
  • single molecule
  • energy transfer
  • molecularly imprinted
  • loop mediated isothermal amplification
  • aqueous solution